Modulate the catalytic rate with the probability of cleavage site being
bound.

For Wee et al., we consider a two state system with and without 3'
supplementary bound.

For Yan et al. model, we consider the 5 discrete states resulting from
the finite state automata and compute their binding energy.

Modulate kcat of individual interactions with the binding probability of
nucleotide surrounding the cleavage site.

Fix missing RT factor in 'binding_energy'.

Regenerate 3mer and 4mer tables.